Page 8 - National Poultry Newspaper

CSIRO researcher and author of the paper Dr Ruhani Singh said the technique was cost-effective and scalable.
The research focussed on two different types of live viruses as proofs of concept – a Newcastle disease vaccine designed to protect poultry and a strain of influenza A. When MOFs were formed around the vaccines, they helped protect the vaccine molecules from heat stress.
“This breakthrough has the potential to enable more affordable and equitable access to vaccines across the world.”
“MOFs work similarly to a scaffold you might put around your house, once you remove the scaf- fold, your house remains – which is what happens when we dissolve the MOFs in a vaccine.”
“This world-first ap- proach of stabilising a vaccine with MOFs is simple, rapid and scalable because it takes one step.”
New research aims to end refrigeration of vaccines
THE World Health Or- ganisation estimates that at least 50 percent of vac- cines are wasted globally each year, with a lack of facilities and temperature control the major cause.
supply chains required to keep the vaccine viable,” Dr Layton said.
CSIRO senior scientist Dr Cara Doherty said MOFs were the perfect material for protecting vaccines from tempera- ture variations.
“You can modify the vaccine – which is com- plex and laborious and at high temperatures may still only last less than aweek–oryoucanuse other stabilising agents which pose challenges, including how to realisti- cally scale up the solu- tion.
Researchers at Australia’s national science agency CSIRO have developed a technique that addresses the challenge of transport- ing temperature-dependent vaccines, which they hope may increase access in ru- ral and remote communi- ties in Australia and devel- oping countries.
“Live virus vaccines are extremely effective, but their complex composition makes them susceptible to high temperatures and a universal stabilisation tech- nique has not been found.
“MOFs are a porous crystalline material that can grow around the vac- cine to form a scaffold that protects against tem- perature variations,” Dr Doherty said.
Recently published in Ac- ta Biomaterialia, CSIRO researchers encapsulated live virus vaccines with a dissolvable crystalline ma- terial called metal organic frameworks, which pro- tected the integrity of the vaccines for up to 12 weeks and at temperatures as high as 37C.
The research focussed on two different types of live viruses as proofs of con- cept – a Newcastle disease vaccine designed to protect poultry and a strain of in- fluenza A.
CSIRO researcher and author of the paper Dr Ruhani Singh said the technique was cost-effec- tive and scalable.
The team continue to progress this research and are looking to partner with animal and human health companies to com- mercialise their work.
Without refrigeration the vaccines would otherwise last only a few days.
A solution was then used that dissolved the MOF for administration of the vac- cine.
“There are two common approaches to protecting vaccines from heat,” Dr Singh said.
CSIRO scientist and im- munologist Dr Daniel Lay- ton said the breakthrough science would now focus on proving the approach for other animal and human vaccines, including mRNA COVID-19 vaccines.
“Vaccination is undoubt- edly one of the most effec- tive medical interventions, saving millions of lives each year, however deliver- ing vaccines – particularly to developing countries – is challenging because they often lack the cold storage
Dr Daniel Layton said the breakthrough has the potential tto enable more afford- able and equitable access to vaccines across the world.
When MOFs were formed around the vaccines, they helped protect the vaccine molecules from heat stress.
Their research forms part of CSIRO’s biomedi- cal research, which is aiming to generate new opportunities for Austral- ian businesses and in- crease national sovereign capability.
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Page 8 – National Poultry Newspaper, March 2022
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